Article
Association of gene polymorphism of polymeric immunoglobulin receptor and IgA nephropathy.
Internal medicine (Tokyo, Japan) - 1 Sept 2001
Narita I, Kondo D, Goto S, Saito N, Watanabe Y, Yamazaki H, Sakatsume M, Saito A, Gejyo F
Abstract excerpt
OBJECTIVE: In order to explore the possibility that genetic predisposition to dysfunction of mucosal immunity and the IgA processing pathway plays a role in the pathogenesis of mesangial IgA1 deposition in IgAN, we examined the possible association of the gene polymorphism of pIgR in the patients with and without IgAN. SUBJECTS AND METHODS: Genomic DNA of peripheral blood cells was isolated from 372 individuals...
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