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Article

Matrix deposition by a calcifying human osteogenic sarcoma cell line (SAOS-2).

Bone - 1 Apr 1995

McQuillan D J, Richardson M D, Bateman J F

Abstract excerpt

Procollagen and proteoglycan biosynthesis was defined in long-term culture of a human osteogenic sarcoma cell line, SAOS-2. An osteoblast phenotype was maintained by these cells up to 40 days post-confluent in the presence of ascorbic acid. Under these conditions, cells deposited around them an extensive collagenous matrix that was able to mineralize in the presence of an exogenous phosphate donor...

Topics

Calcinosis
Cell Division
Chromatography, Gel
Chromatography, Ion Exchange
Collagen
Extracellular Matrix
Glycerophosphates
Humans
Osteoblasts
Osteosarcoma
Phenotype
Procollagen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proteoglycans

Sulfur Radioisotopes

Tumor Cells, Cultured

Source

Identifiers

PMID: 7605701
DOI: 10.1016/8756-3282(95)90186-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7605701-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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