Article
Mitochondrial DNA mutations in cardiomyopathy: combination of replacements yielding cysteine residues and tRNA mutations.
Muscle & nerve. Supplement - 1 Jan 1995
Tanaka M, Obayashi T, Yoneda M, Kovalenko S A, Sugiyama S, Ozawa T
Abstract excerpt
Mutations occur in mitochondrial DNA (mtDNA) in a strand-asymmetric manner. The suppressed usage of cysteine residues in the H-strand-encoded subunits can be ascribed to the mutational instability of the codon for cysteine. The usage of cysteine was suppressed even in the L-strand-encoded ND6 subunit in which the codon for cysteine was stable. Survey of the entire sequences of mtDNA from 43 individuals revealed...
Topics
- Adult
- Amino Acid Sequence
- Cardiomyopathies
- Cardiomyopathy, Hypertrophic
- Codon
- Cysteine
- DNA, Mitochondrial
- Humans
- Infant
- Male
- Molecular Sequence Data