Article
Single copy heterozygote integration of HPV 33 in chromosomal band 5p14 is found in an epithelial cell clone with selective growth advantage.
Carcinogenesis - 1 Jun 2002
Peitsaro Panu, Hietanen Sakari, Johansson Bo, Lakkala Taina, Syrjänen Stina
Abstract excerpt
Infection with human papillomavirus (HPV) of specific high-risk type triggers a series of events in target cells, which will eventually lead to development of genital neoplasia. The integration of high-risk HPV DNA into the cell genome has been regarded as a crucial event in tumor progression. With respect to different HPV types, the knowledge of HPV integrated loci is still limited. We have now determined the...
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