Presence and persistence of HPV infection and p53 mutation in cancer of the cervix uteri and the vulva.

doi:10.1002/ijc.2910630507

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Article

Presence and persistence of HPV infection and p53 mutation in cancer of the cervix uteri and the vulva.

International journal of cancer - 27 Nov 1995

Milde-Langosch K, Albrecht K, Joram S, Schlechte H, Giessing M, Löning T

Abstract excerpt

We studied 51 cervical carcinomas, among them 25 squamous-cell carcinomas (SCC) and 26 cervical adenocarcinomas (AdCa), and 40 vulvar SCC for the presence of HPV and mutant p53. HPV was detected by PCR, and p53 alterations by temperature-gradient gel electrophoresis/direct sequencing and immunohistochemistry. HPV, mostly type 16/18, was found in 80.4% of the cervical tumors (92.0% of the SCC and 69.2% of the...

Topics

Adenocarcinoma
Adult
Aged
Aged, 80 and over
Base Sequence
Carcinoma, Squamous Cell
Female
Genes, p53
Humans
Middle Aged
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Papillomaviridae

Papillomavirus Infections

Prognosis

Tumor Suppressor Protein p53

Tumor Virus Infections

Uterine Cervical Neoplasms

Source

Open in PubMed

Identifiers

PMID: 7591279
DOI: 10.1002/ijc.2910630507

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7591279-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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