Article
Human papillomavirus, Epstein-Barr virus and p53 mutation in vulvar intraepithelial neoplasia.
The Journal of reproductive medicine - 1 Oct 2004
Almeida Gutemberg, do Val Isabel, Gondim Consuelo, Lima Roberto, Takiya Cristina, Carvalho Gloria
Abstract excerpt
OBJECTIVE: To clarify the role of human papillomavirus (HPV) and Epstein-Barr virus (EBV) infection in vulvar carcinogenesis in relation to the mutated p53 gene. STUDY DESIGN: Polymerase chain reaction (PCR) was used to amplify DNA sequences of the viruses and PCR-single-strand conformation polymorphism analysis to screen for p53 gene mutations in exons 5-8 from formalin-fixed, paraffin-embedded blocks including...
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