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Article

Human papillomavirus, Epstein-Barr virus and p53 mutation in vulvar intraepithelial neoplasia.

The Journal of reproductive medicine - 1 Oct 2004

Almeida Gutemberg, do Val Isabel, Gondim Consuelo, Lima Roberto, Takiya Cristina, Carvalho Gloria

Abstract excerpt

OBJECTIVE: To clarify the role of human papillomavirus (HPV) and Epstein-Barr virus (EBV) infection in vulvar carcinogenesis in relation to the mutated p53 gene. STUDY DESIGN: Polymerase chain reaction (PCR) was used to amplify DNA sequences of the viruses and PCR-single-strand conformation polymorphism analysis to screen for p53 gene mutations in exons 5-8 from formalin-fixed, paraffin-embedded blocks including...

Topics

Adult
Aged
Base Sequence
Carcinoma in Situ
Cohort Studies
DNA Probes, HPV
DNA, Viral
Female
Gene Expression Regulation, Neoplastic
Genes, p53
Herpesvirus 4, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Middle Aged

Molecular Sequence Data

Mutation

Papillomaviridae

Polymerase Chain Reaction

Prognosis

Source

Identifiers

PMID: 15568402

Provenance

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