Article
Evidence on N-acetyltransferase allele-associated metabolism of hydrazine in Japanese workers.
Journal of occupational and environmental medicine - 1 Mar 1998
Koizumi A, Nomiyama T, Tsukada M, Wada Y, Omae K, Tanaka S, Miyauchi H, Imamiya S, Sakurai H
Abstract excerpt
Hydrazine (N2H4), which has been categorized as a weak carcinogen, is a chemical with the one of the largest production rates in Japan. We have investigated the effects of acetylation phenotypes on the metabolism of hydrazine. Genotypes of N-acetyl transferases, NAT2*, were determined using polymerase chain reaction for 297 male workers. Biological and exposure monitoring were also conducted. The rapid and...
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