Tumour suppression by the human von Hippel-Lindau gene product.

doi:10.1038/nm0895-822

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Article

Tumour suppression by the human von Hippel-Lindau gene product.

Nature medicine - 1 Aug 1995

Iliopoulos O, Kibel A, Gray S, Kaelin W G

Abstract excerpt

A partial cDNA sequence for the gene linked to the von Hippel-Lindau (VHL) syndrome was reported in 1993. Mutation or loss of both VHL alleles has been documented in sporadic renal cell carcinomas and in the neoplasms that arise in von Hippel-Lindau kindreds. We have determined that the protein p...

Topics

Amino Acid Sequence
Base Sequence
Blotting, Northern
Carcinoma
Cell Compartmentation
Cell Transformation, Neoplastic
Cytoplasm
Fluorescent Antibody Technique
Genes, Tumor Suppressor
Humans
Kidney Neoplasms
Ligases
Molecular Sequence Data
Mutation
Peptide Mapping
Protein Biosynthesis
Proteins
Recombinant Fusion Proteins

Source

Open in PubMed

Identifiers

PMID: 7585187
DOI: 10.1038/nm0895-822

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7585187-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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