In vitro stimulation of tissue-type plasminogen activator by Alzheimer amyloid beta-peptide analogues.

doi:10.1038/nm0295-138

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Article

In vitro stimulation of tissue-type plasminogen activator by Alzheimer amyloid beta-peptide analogues.

Nature medicine - 1 Feb 1995

Kingston I B, Castro M J, Anderson S

Abstract excerpt

We have studied the effects of amyloid beta-peptide analogues on the activity of tissue-type plasminogen activator (t-PA) in vitro. We have found that these peptides have a marked stimulatory effect upon plasminogen activation by t-PA, comparable to that of known stimulators of t-PA. This stimula...

Topics

Amino Acid Sequence
Amyloid beta-Peptides
Fibrinogen
Humans
Kinetics
Molecular Sequence Data
Mutation
Peptide Fragments
Tissue Plasminogen Activator

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