Lymphohematopoietic Engraftment in Minimally Myeloablated Hosts

Abstract excerpt

The concept that myeloablation to open space was a prerequisite for marrow stem cell engraftment has been challenged by studies showing high rates of engraftment in nonmyeloablated mice (Stewart et al, Blood 81:2566, 1993; Quesenberry et al, Blood Cells 20:97, 1994; Brecher et al, Blood Cells 5:237, 1979; Saxe et al, Exp Hematol 12:277, 1984; and Wu et al, Exp Hematol 21:251, 1993). However, relatively large...

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