Article
Analysis of beta-globin mutations shows stable mixed chimerism in patients with thalassemia after bone marrow transplantation.
Blood - 15 Oct 1995
Kapelushnik J, Or R, Filon D, Nagler A, Cividalli G, Aker M, Naparstek E, Slavin S, Oppenheim A
Abstract excerpt
Beta-thalassemia major (TM) is caused by any of approximately 150 mutations within the beta-globin gene. To establish the degree of chimerism after bone marrow transplantation (BMT), we have performed molecular analysis of beta-globin mutations in 14 patients with TM over a period of 10 years. All patients underwent T cell-depleted allogeneic BMT from HLA-identical related donors, using either in vitro T-cell...
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