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Mixed chimerism in haemoglobinopathies: from risk of graft rejection to immune tolerance

20 Feb 2014

Abstract excerpt

Mixed chimerism (MC), the simultaneous presence of both host- and donor-derived cells in the recipient, is observed in a large proportion of patients after haematopoietic stem cell transplant (HSCT) to treat haemoglobinopathies. Detected early after transplantation, MC often moves towards complete chimerism, although sometimes it may evolve into graft rejection, especially if the proportion of donor cells is very...

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PMID: 24571472
DOI: 10.1111/tan.12313

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