Article
Clinical relevance of serial quantitative analysis of hematopoietic chimerism after allogeneic stem cell transplantation in children for severe aplastic anemia.
Bone marrow transplantation - 1 Jan 2004
Hoelle W, Beck J F, Dueckers G, Kreyenberg H, Lang P, Gruhn B, Führer M, Niethammer D, Klingebiel T, Bader P
Abstract excerpt
Allogeneic stem cell transplantation (allo-SCT) is a well-established treatment modality for children with severe aplastic anemia (SAA). Treatment failures are rare and mostly caused by graft rejection. Increasing mixed chimerism represents a stage at the very beginning of graft rejection, where immunological intervention might be an effective prophylactic approach. To substantiate this, we: (1) monitored...
Topics
- Adolescent
- Anemia, Aplastic
- Child
- Child, Preschool
- Graft Rejection
- Graft vs Host Disease
- Hematopoietic Stem Cell Transplantation
- Humans
- Immunosuppressive Agents
- Phenotype
- Risk Factors
- Severity of Illness Index
- Transplantation Chimera