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Article

Cell renewing in neuroblastoma: electrophysiological and immunocytochemical characterization of stem cells and derivatives.

Stem cells (Dayton, Ohio) - 1 Feb 2006

Biagiotti Tiziana, D'Amico Massimo, Marzi Ilaria, Di Gennaro Paola, Arcangeli Annarosa, Wanke Enzo, Olivotto Massimo

Abstract excerpt

We explored the stem cell compartment of the SH-SY5Y neuroblastoma (NB) clone and its development by a novel approach, integrating clonal and immunocytochemical investigations with patch-clamp measurements of ion currents simultaneously expressed on single cells. The currents selected were the triad IHERG, IKDR, INa, normally expressed at varying mutual ratios during development of neural crest stem cells, from...

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Identifiers

PMID: 16100002
DOI: 10.1634/stemcells.2004-0264

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