An urbilaterian origin of the tripartite brain: developmental genetic insights from Drosophila.

doi:10.1242/dev.00438

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Article

An urbilaterian origin of the tripartite brain: developmental genetic insights from Drosophila.

Development (Cambridge, England) - 1 Jun 2003

Hirth Frank, Kammermeier Lars, Frei Erich, Walldorf Uwe, Noll Markus, Reichert Heinrich

Abstract excerpt

Studies on expression and function of key developmental control genes suggest that the embryonic vertebrate brain has a tripartite ground plan that consists of a forebrain/midbrain, a hindbrain and an intervening midbrain/hindbrain boundary region, which are characterized by the specific expression of the Otx, Hox and Pax2/5/8 genes, respectively. We show that the embryonic brain of the fruitfly Drosophila...

Topics

Animals
Animals, Genetically Modified
Brain
DNA-Binding Proteins
Drosophila Proteins
Drosophila melanogaster
Gene Expression Regulation, Developmental
Genes, Homeobox
Genes, Insect
Homeodomain Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nerve Tissue Proteins

PAX2 Transcription Factor

Paired Box Transcription Factors

Species Specificity

Transcription Factors

Vertebrates

Source

Open in PubMed

Identifiers

PMID: 12702651
DOI: 10.1242/dev.00438

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