Article
Characterization and prevalence of a polymorphism in the 3' untranslated region of cytochrome P4501A1 in cancer-prone Atlantic tomcod.
Archives of biochemistry and biophysics - 10 Sept 1995
Roy N K, Kreamer G L, Konkle B, Grunwald C, Wirgin I
Abstract excerpt
Atlantic tomcod (Microgadus tomcod) from the cancer-prone Hudson River population exhibit a genetic polymorphism in the cytochrome P4501A (CYP1A) gene which is evidenced in Northern blot analyses by a truncated transcript and in Southern blot analyses by a deletion in the variant allele. To initially evaluate the functional significance of this polymorphism, we sought to characterize the molecular basis for this...
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