Article
Mechanistic basis of resistance to PCBs in Atlantic tomcod from the Hudson River.
Science (New York, N.Y.) - 11 Mar 2011
Wirgin Isaac, Roy Nirmal K, Loftus Matthew, Chambers R Christopher, Franks Diana G, Hahn Mark E
Abstract excerpt
The mechanistic basis of resistance of vertebrate populations to contaminants, including Atlantic tomcod from the Hudson River (HR) to polychlorinated biphenyls (PCBs), is unknown. HR tomcod exhibited variants in the aryl hydrocarbon receptor 2 (AHR2) that were nearly absent elsewhere. In ligand-binding assays, AHR2-1 protein (common in the HR) was impaired as compared to widespread AHR2-2 in binding TCDD...
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