Familial cosegregation of manic-depressive illness and a form of hereditary cerebellar ataxia.

doi:10.1002/ajmg.1320600307

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Article

Familial cosegregation of manic-depressive illness and a form of hereditary cerebellar ataxia.

American journal of medical genetics - 19 Jun 1995

Fernández Piqueras J, Santos J, Visedo G, Pérez de Castro I, Puertollano R, Montejo J, Ramo Tello C, Valle J

Abstract excerpt

We report on a Spanish family with cooccurrence of manic-depression and a form of hereditary cerebellar ataxia. All affected individuals in the second generation showed cerebellar ataxia and manic-depression simultaneously. Since anticipation has been described in both disorders and the pattern of segregation may be autosomal as well as X-linked, we have searched for a possible involvement of two candidate genes...

Topics

Adolescent
Adult
Ataxin-1
Ataxins
Biomarkers
Bipolar Disorder
Cerebellar Ataxia
Chromosome Mapping
Female
Humans
Magnetic Resonance Imaging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mutation

Nerve Tissue Proteins

Nuclear Proteins

Pedigree

Radiography

Spain

Source

Open in PubMed

Identifiers

PMID: 7573172
DOI: 10.1002/ajmg.1320600307

Genes

GABRA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7573172-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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