Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15.

doi:10.1126/science.270.5233.86

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Article

Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15.

Science (New York, N.Y.) - 6 Oct 1995

Mueller P R, Coleman T R, Kumagai A, Dunphy W G

Abstract excerpt

Cdc2 is the cyclin-dependent kinase that controls entry of cells into mitosis. Phosphorylation of Cdc2 on threonine-14 and tyrosine-15 inhibits the activity of the enzyme and prevents premature initiation of mitosis. Although Wee1 has been identified as the kinase that phosphorylates tyrosine-15 in various organisms, the threonine-14-specific kinase has not been isolated. A complementary DNA was cloned from...

Topics

Amino Acid Sequence
Animals
Base Sequence
CDC2 Protein Kinase
Cell Cycle Proteins
Cell Membrane
Cloning, Molecular
Cyclins
Interphase
Mitosis
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nuclear Proteins

Oocytes

Phosphorylation

Phosphothreonine

Phosphotyrosine

Protein Serine-Threonine Kinases

Source

Open in PubMed

Identifiers

PMID: 7569953
DOI: 10.1126/science.270.5233.86

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7569953-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15.PMID 7569953Read ↗

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