A nonlethal rat parvovirus infection suppresses rat T lymphocyte effector functions.

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Article

A nonlethal rat parvovirus infection suppresses rat T lymphocyte effector functions.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 1995

McKisic M D, Paturzo F X, Gaertner D J, Jacoby R O, Smith A L

Abstract excerpt

Inoculation of the UMass strain of rat virus (RV-UMass) into adult immunocompetent rats results in a prolonged subclinical infection that is resolved in 4 to 8 wk. Co-labeling studies, using in situ hybridization (ISH) and immunohistochemistry (IHC), confirmed that RV-UMass was lymphocytotropic and capable of infecting CD4+ and CD8+ T cells as well as B cells. ISH studies also revealed that virus replication was...

Topics

Animals
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Cell Line
Cytotoxicity, Immunologic
Disease Susceptibility
Immune Tolerance
Lymphocyte Activation
Parvoviridae Infections
Parvovirus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Rats

Rats, Inbred Lew

Rats, Inbred WF

Species Specificity

T-Lymphocyte Subsets

Source

Open in PubMed

Identifiers

PMID: 7561106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7561106-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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