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Article

Parvovirus nonstructural proteins induce an epigenetic modification through histone acetylation in host genes and revert tumor malignancy to benignancy.

Journal of virology - 1 Jul 2005

Iseki Hiroyoshi, Shimizukawa Rie, Sugiyama Fumihiro, Kunita Satoshi, Iwama Atsushi, Onodera Masafumi, Nakauchi Hiromitsu, Yagami Ken-ichi

Abstract excerpt

Several malignant tumor cells become apoptotic and revert to the benign phenotype upon parvovirus infection. Recently, we demonstrated that the rat parvovirus RPV/UT also induces apoptosis in the rat thymic lymphoma cell line C58(NT)D. However, a minority of cells that escaped apoptosis showed properties different from the parental cells, such as resistance to apoptosis, enhanced cell adherence, and suppressed...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15994782
DOI: 10.1128/JVI.79.14.8886-8893.2005
PMCID: PMC1168790

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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