Article
Propagation of rat parvovirus in thymic lymphoma cell line C58(NT)d and subsequent appearance of a resistant cell clone after lytic infection.
Journal of virology - 1 Apr 2001
Ueno Y, Harada T, Iseki H, Ohshima T, Sugiyama F, Yagami K
Abstract excerpt
Rat parvovirus (RPV) is nonpathogenic in rats but causes persistent lymphocytotropic infection. We found that RPV was propagated in rat thymic lymphoma cell line C58(NT)D and induced apoptosis. Interestingly, a resistant subclone, C58(NT)D/R, from surviving cells after lytic infection had differentiated phenotypic modifications, such as increased cell adherence, resistance to apoptosis, and suppressed tumorigenicity.
Topics
- Animals
- Apoptosis
- Cell Adhesion
- Cell Differentiation
- Cell Line
- Cell Transformation, Neoplastic
- Clone Cells
- Lymphoma
- Mice
- Mice, Nude
- Neoplasm Transplantation
- Parvovirus
- Phenotype
- Rats
- Serial Passage