A mouse model for the cystic fibrosis delta F508 mutation.

doi:10.1002/j.1460-2075.1995.tb00119.x

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Article

A mouse model for the cystic fibrosis delta F508 mutation.

The EMBO journal - 15 Sept 1995

van Doorninck J H, French P J, Verbeek E, Peters R H, Morreau H, Bijman J, Scholte B J

Abstract excerpt

Most cystic fibrosis (CF) patients produce a mutant form (delta F508) of the cystic fibrosis transmembrane conductance regulator (CFTR), which is not properly processed in normal cells but is active as a chloride channel in several experimental systems. We used a double homologous recombination (...

Topics

Animals
Base Sequence
Clone Cells
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
Disease Models, Animal
Exons
Gallbladder
Gene Targeting
Heterozygote
Homozygote
Intestine, Small

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Mutant Strains

Molecular Sequence Data

Mutation

Nasal Mucosa

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 7556083
DOI: 10.1002/j.1460-2075.1995.tb00119.x
PMCID: PMC394531

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7556083-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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