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Article

A mouse model for the cystic fibrosis delta F508 mutation.

The EMBO journal - 15 Sept 1995

van Doorninck J H, French P J, Verbeek E, Peters R H, Morreau H, Bijman J, Scholte B J

Abstract excerpt

Most cystic fibrosis (CF) patients produce a mutant form (delta F508) of the cystic fibrosis transmembrane conductance regulator (CFTR), which is not properly processed in normal cells but is active as a chloride channel in several experimental systems. We used a double homologous recombination ('Hit and Run') procedure to generate a mouse model for the delta F508 mutation. Targeted embryonic stem (ES) cells (Hit...

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Identifiers

PMID: 7556083
DOI: 10.1002/j.1460-2075.1995.tb00119.x
PMCID: PMC394531

Genes

CFTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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