Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted Integration of a Super-Exon into the CFTR Locus Leads to Functional Correction of a Cystic Fibrosis Cell Line Model.

PloS one - 1 Jan 2016

Bednarski Christien, Tomczak Katja, Vom Hövel Beate, Weber Wolf-Michael, Cathomen Toni

Abstract excerpt

In vitro disease models have enabled insights into the pathophysiology of human disease as well as the functional evaluation of new therapies, such as novel genome engineering strategies. In the context of cystic fibrosis (CF), various cellular disease models have been established in recent years, including organoids based on induced pluripotent stem cell technology that allowed for functional readouts of CFTR...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cystic Fibrosis
Share to Cystic Fibrosis Transmembrane Conductance Regulator

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Deoxyribonucleases

Share to DNA, Complementary

Share to Epithelial Cells

Share to Gene Editing

Share to Genetic Loci

Share to Zinc Fingers

Source

Open in PubMed Open full text

Identifiers

PMID: 27526025
DOI: 10.1371/journal.pone.0161072
PMCID: PMC4985144

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted Integration of a Super-Exon into the CFTR Locus Leads to Functional Correction of a Cystic Fibrosis Cell Line Model.PMID 27526025Read ↗

Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs.Semantic proximity Read ↗

iPSC-Derived Intestinal Organoids from Cystic Fibrosis Patients Acquire CFTR Activity upon TALEN-Mediated Repair of the p.F508del MutationSemantic proximity Read ↗

Rewriting CFTR to cure cystic fibrosis.Semantic proximity Read ↗

On the Corner of Models and Cure: Gene Editing in Cystic FibrosisSemantic proximity Read ↗

Genome Editing for Cystic FibrosisSemantic proximity Read ↗

Highly Efficient Gene Editing of Cystic Fibrosis Patient-Derived Airway Basal Cells Results in Functional CFTR Correction.Semantic proximity Read ↗

Gene Therapy for Cystic Fibrosis: Progress and Challenges of Genome Editing.Semantic proximity Read ↗

Molecular and functional correction of a deep intronic splicing mutation in CFTR by CRISPR-Cas9 gene editingSemantic proximity Read ↗

Base editing and nanoparticle transfection of airway cell types essential for treatment of cystic fibrosisSemantic proximity Read ↗

Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis PatientsSemantic proximity Read ↗

Personalized medicine for cystic fibrosis: establishing human model systems.Semantic proximity Read ↗

High-Throughput Screening for Modulators of CFTR Activity Based on Genetically Engineered Cystic Fibrosis Disease-Specific iPSCsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.