Article
Tetrahydrobiopterin deficiency and brain nitric oxide synthase in the hph1 mouse.
Journal of inherited metabolic disease - 1 Jan 1995
Brand M P, Heales S J, Land J M, Clark J B
Abstract excerpt
Tetrahydrobiopterin (BH4) is the cofactor for the aromatic amino acid monoxygenase group of enzymes and for all known isoforms of nitric oxide synthase (NOS). Inborn errors of BH4 metabolism lead to hyperphenylalaninaemia and impaired catecholamine and serotonin turnover. The effects of BH4 defic...
Topics
- Amino Acid Oxidoreductases
- Animals
- Arginine
- Biopterins
- Brain
- GTP Cyclohydrolase
- Kinetics
- Metabolism, Inborn Errors
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Mutation
- Nitric Oxide Synthase