Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dwarfism and low insulin-like growth factor-1 due to dopamine depletion in Pts-/- mice rescued by feeding neurotransmitter precursors and H4-biopterin.

The Journal of biological chemistry - 25 Jul 2003

Elzaouk Lina, Leimbacher Walter, Turri Matteo, Ledermann Birgit, Burki Kurt, Blau Nenad, Thony Beat

Abstract excerpt

The tetrahydrobiopterin (BH4) cofactor is essential for the biosynthesis of catecholamines and serotonin and for nitric-oxide synthase (NOS). Alterations in BH4 metabolism are observed in various neurological and psychiatric diseases, and mutations in one of the human metabolic genes causes hyperphenylalaninemia and/or monoamine neurotransmitter deficiency. We report on a knockout mouse for the Pts gene, which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biopterins
Share to Dwarfism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin-Like Growth Factor I

Share to Neurotransmitter Agents

Share to Nitric Oxide

Share to Nitric Oxide Synthase

Share to Phosphorus-Oxygen Lyases

Share to Thyroxine

Source

Identifiers

PMID: 12734191
DOI: 10.1074/jbc.M303986200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dwarfism and low insulin-like growth factor-1 due to dopamine depletion in Pts-/- mice rescued by feeding neurotransmitter precursors and H4-biopterin.PMID 12734191Read ↗

Mildly compromised tetrahydrobiopterin cofactor biosynthesis due to Pts variants leads to unusual body fat distribution and abdominal obesity in mice.Semantic proximity Read ↗

A murine model for human sepiapterin-reductase deficiency.Semantic proximity Read ↗

Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neuronsSemantic proximity Read ↗

Genetic and pharmacological correction of aberrant dopamine synthesis using patient iPSCs with BH4 metabolism disorders.Semantic proximity Read ↗

Inherited disorders affecting dopamine and serotonin: critical neurotransmitters derived from aromatic amino acids.Semantic proximity Read ↗

Mutations in the sepiapterin reductase gene cause a novel tetrahydrobiopterin-dependent monoamine-neurotransmitter deficiency without hyperphenylalaninemia.Semantic proximity Read ↗

Molecular and metabolic bases of tetrahydrobiopterin (BH4) deficiencies.Semantic proximity Read ↗

Mutations in the BH4-metabolizing genes GTP cyclohydrolase I, 6-pyruvoyl-tetrahydropterin synthase, sepiapterin reductase, carbinolamine-4a-dehydratase, and dihydropteridine reductase.Semantic proximity Read ↗

Isolated central form of tetrahydrobiopterin deficiency associated with hemizygosity on chromosome 11q and a mutant allele of PTPS.Semantic proximity Read ↗

Novel mutation affecting the pterin-binding site of PTS gene and review of PTS mutations in Thai patients with 6-pyruvoyltetrahydropterin synthase deficiency.Semantic proximity Read ↗

Potential therapeutic applications of tetrahydrobiopterin: from inherited hyperphenylalaninemia to mitochondrial diseases.Semantic proximity Read ↗

Molecular analysis and long-term follow-up of patients with different forms of 6-pyruvoyl-tetrahydropterin synthase deficiency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.