Article
ras, p53 and HPV status in benign and malignant prostate tumors.
International journal of cancer - 21 Apr 1995
Moyret-Lalle C, Marçais C, Jacquemier J, Moles J P, Daver A, Soret J Y, Jeanteur P, Ozturk M, Theillet C
Abstract excerpt
To study the role of ras, p53 genes and HPV virus (16 and 18) in the development of prostate cancer, we analyzed tissue sections from 27 patients affected with carcinomas (stages A to D) and from 24 patients with adenomas. Mutations of H, K and N-ras and p53 (exons 2-9) were studied by SSCP and DNA sequencing. Accumulation of p53 protein was studied by immunohistochemistry on tissue sections. Tumors were also...
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