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Article

Expression of CD45RB and CD27 identifies subsets of CD4+ memory T cells with different capacities to induce B cell differentiation.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 1995

Tortorella C, Schulze-Koops H, Thomas R, Splawski J B, Davis L S, Picker L J, Lipsky P E

Abstract excerpt

The capacity of four subsets of CD4+ memory T cells, defined by expression of CD45RB and CD27, to provide help for B cells was examined. Larger amounts of Ig were induced by CD45RBdimCD27- cells compared with the CD45RBdimCD27+ population, whereas CD45RBbrightCD27+ or CD27- cells were poor inducers of Ig synthesis. Mitomycin C treatment, which prevents suppressive activity, markedly enhanced Ig production...

Topics

Adult
Antigens, CD
Antigens, Differentiation, B-Lymphocyte
B-Lymphocytes
CD4-Positive T-Lymphocytes
CD40 Antigens
Cell Differentiation
Cells, Cultured
Humans
Immunoglobulins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunologic Memory

Interferon-gamma

Interleukin-10

Interleukin-2

Interleukin-4

Kinetics

Leukocyte Common Antigens

Lymphocyte Activation

Source

Identifiers

PMID: 7541412

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7541412-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Expression of CD45RB and CD27 identifies subsets of CD4+ memory T cells with different capacities to induce B cell differentiation.PMID 7541412Read ↗

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