Production of monoclonal antibodies specific to the carboxyl terminal region of the 85 kDa subunit of phosphatidylinositol 3-kinase: use of the antibodies in recognition of mutant p85.

doi:10.1038/icb.1995.21

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Article

Production of monoclonal antibodies specific to the carboxyl terminal region of the 85 kDa subunit of phosphatidylinositol 3-kinase: use of the antibodies in recognition of mutant p85.

Immunology and cell biology - 1 Apr 1995

Daduang S, Nagata S, Matsuda M, Yamori T, Onodera K, Fukui Y

Abstract excerpt

We have established two hybridomas producing mAb to the carboxyl terminal region of phosphatidylinositol-3 kinase 85 kDa subunit type alpha (p85 alpha). Analysis using deletion mutants of p85 revealed that epitopes for the two mAb were located on the border of the src homology 2 (SH2) sequence lo...

Topics

Animals
Antibodies, Monoclonal
Antibody Specificity
Antigen-Antibody Reactions
Colonic Neoplasms
Epitopes
Female
Genes, src
Haplorhini
Humans
Immunoblotting
Mice
Mice, Inbred BALB C
Mutation
Phosphatidylinositol 3-Kinases

Source

Open in PubMed

Identifiers

PMID: 7541019
DOI: 10.1038/icb.1995.21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7541019-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Phosphotransferases (Alcohol Group Acceptor)

Precipitin Tests

Sequence Homology, Amino Acid