Article
Heterogeneity of the Epstein-Barr Virus (EBV) Major Internal Repeat Reveals Evolutionary Mechanisms of EBV and a Functional Defect in the Prototype EBV Strain B95-8.
Journal of virology - 1 Dec 2017
Ba Abdullah Mohammed M, Palermo Richard D, Palser Anne L, Grayson Nicholas E, Kellam Paul, Correia Samantha, Szymula Agnieszka, White Robert E
Abstract excerpt
Epstein-Barr virus (EBV) is a ubiquitous pathogen of humans that can cause several types of lymphoma and carcinoma. Like other herpesviruses, EBV has diversified through both coevolution with its host and genetic exchange between virus strains. Sequence analysis of the EBV genome is unusually challenging because of the large number and lengths of repeat regions within the virus. Here we describe the sequence...
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