Article
Abnormal subcellular localization of mutated CFTR protein in a cystic fibrosis epithelial cell line.
European journal of cell biology - 1 Oct 1994
Demolombe S, Baró I, Laurent M, Hongre A S, Pavirani A, Escande D
Abstract excerpt
The cystic fibrosis gene product, CFTR, is a Cl- channel that possesses specific binding sites for cytosolic ATP and is activated by cAMP-dependent protein kinase. Most recently, it was reported that CFTR localizes at the surface apical compartment of normal airway epithelial cells, but accumulates in the cytosol of airway cells from CF patients with the delta F508 mutation. In order to explore whether the same...
Topics
- Cell Line
- Cell Membrane Permeability
- Chloride Channels
- Colonic Neoplasms
- Cyclic AMP
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Epithelium
- Humans
- Immunohistochemistry
- Membrane Proteins