[Oncogenes and mitotic regulators: a change in perspective of our view of neoplastic processes].

doi:10.1051/medsci/2003192187

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Article

[Oncogenes and mitotic regulators: a change in perspective of our view of neoplastic processes].

Medecine sciences : M/S - 1 Feb 2003

Blanchard Jean-Marie

Abstract excerpt

Our vision of the cancer cell has dramatically changed since the discovery of proto-oncogenes, whose deregulation was proposed to mimic normal growth signalling. This notion, linking cancer to cell signalling pathways, has progressively led the way to the concept of the mutator phenotype, in which genetic instability plays an essential role in the onset of cancer. This then transformed cancer into a DNA repair...

Topics

Cell Transformation, Neoplastic
Gene Expression Regulation, Neoplastic
Humans
Mitosis
Mutation
Neoplasms
Oncogenes
Phenotype

Source

Open in PubMed

Identifiers

PMID: 12836613
DOI: 10.1051/medsci/2003192187

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