Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

β/A4‐evoked degeneration of differentiated SH‐SY5Y human neuroblastoma cells

1 Nov 1994

Abstract excerpt

beta/A4 peptides are known to induce neurodegeneration in cultures of rat brain cells and rat neural cell lines (Yankner et al: Science 250:279-282, 1990; Behl et al: Biochem Biophys Res Commun 186:944-950, 1992). The current data show that these peptides induce similar neurodegeneration in SH-SY5Y neuroblastoma cells, extending characterization of beta/A4 toxicity to a human nerve cell line. Human SH-SY5Y cells...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to S100 Proteins and Annexins
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7533843
DOI: 10.1002/jnr.490390404

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

β/A4‐evoked degeneration of differentiated SH‐SY5Y human neuroblastoma cellsPMID 7533843Read ↗

Toxicity of Amyloid-β Peptides Varies Depending on Differentiation Route of SH-SY5Y CellsSemantic proximity Read ↗

Anti-oligomeric Aβ Single-chain Variable Domain Antibody Blocks Aβ-induced Toxicity Against Human Neuroblastoma CellsSemantic proximity Read ↗

Neuron-selective toxicity of tau peptide in a cell culture model of neurodegenerative tauopathy: essential role for aggregation in neurotoxicity.Semantic proximity Read ↗

Increased susceptibility to Aβ toxicity in neuronal cultures derived from familial Alzheimer’s disease (PSEN1-A246E) induced pluripotent stem cellsSemantic proximity Read ↗

Amyloid-β oligomers synaptotoxicity: The emerging role of EphA4/c-Abl signaling in Alzheimer's diseaseSemantic proximity Read ↗

The correlation between neurotoxicity, aggregative ability and secondary structure studied by sequence truncated Aβ peptidesSemantic proximity Read ↗

Time course of Tau toxicity and pharmacologic prevention in a cell model of Tauopathy.Semantic proximity Read ↗

Interleukin-4 restores neurogenic plasticity of the primary human neural stem cells through suppression of Kynurenic acid production upon Amyloid-beta42 toxicitySemantic proximity Read ↗

Antibodies raised against a structurally defined Aβ oligomer mimic protect human iPSC neurons from Aβ toxicity at sub-stoichiometric concentrationsSemantic proximity Read ↗

Accelerated α-synuclein aggregation after differentiation of SH-SY5Y neuroblastoma cellsSemantic proximity Read ↗

<i>In situ</i> generation of Aβ <sub>42</sub> oligomers via secondary nucleation triggers neurite degeneration and synaptic dysfunction in human iPSC-derived glutamatergic neuronsSemantic proximity Read ↗

A Soft Mechanical Phenotype of SH-SY5Y Neuroblastoma and Primary Human Neurons Is Resilient to Oligomeric Aβ(1-42) Injury.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.