Isolation and initial characterization of a series of Chlamydia trachomatis isolates selected for hydroxyurea resistance by a stepwise procedure.

doi:10.1128/jb.173.16.4932-4940.1991

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Article

Isolation and initial characterization of a series of Chlamydia trachomatis isolates selected for hydroxyurea resistance by a stepwise procedure.

Journal of bacteriology - 1 Aug 1991

Tipples G, McClarty G

Abstract excerpt

Chlamydiae are obligate intracellular bacteria that are dependent on eukaryotic host cells for ribonucleoside triphosphates but not deoxyribonucleotide triphosphates. Ribonucleotide reductase is the only enzyme known to catalyze the direct conversion of a ribonucleotide to a deoxyribonucleotide....

Topics

Adenine
Animals
Chlamydia trachomatis
Cytidine Diphosphate
DNA, Bacterial
Drug Resistance, Microbial
Guanazole
Hydroxyurea
L Cells
Mutation
Ribonucleotide Reductases
Selection, Genetic

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