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Article

Rifampin-resistant RNA polymerase mutants of Chlamydia trachomatis remain susceptible to the ansamycin rifalazil.

Antimicrobial agents and chemotherapy - 1 Mar 2005

Suchland Robert J, Bourillon Agnès, Denamur Erick, Stamm Walter E, Rothstein David M

Abstract excerpt

Stable, homotypic mutants of Chlamydia trachomatis for which MICs of rifampin and rifalazil are elevated were isolated by serial passage at sub-MIC concentrations of these compounds. An alternative approach, in which Chlamydia cells were incubated and subsequently passaged three times, all in the presence of the selective agent at concentrations above the MIC, appeared to be a more effective means of selecting...

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Source

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Identifiers

PMID: 15728912
DOI: 10.1128/AAC.49.3.1120-1126.2005
PMCID: PMC549232

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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