Article
The anticonvulsant effect of the broad spectrum anticonvulsant loreclezole may be mediated in part by serotonin in rats: a microdialysis study.
Neuroscience letters - 12 Sept 1994
Dailey J W, Seo D O, Yan Q S, Ko K H, Jo M, Jobe P C
Abstract excerpt
Loreclezole is an experimental anticonvulsant drug. We found previously that several established anticonvulsants increase extracellular serotonin as measured by microdialysis. We have concluded that the increase in extracellular serotonin and the anticonvulsant effect produced by these anticonvul...
Topics
- Acoustic Stimulation
- Animals
- Anticonvulsants
- Dose-Response Relationship, Drug
- Epilepsy
- Genetic Predisposition to Disease
- Hydroxyindoleacetic Acid
- Microdialysis
- Rats
- Rats, Sprague-Dawley
- Serotonin
- Triazoles