Article
Founder effect at PGL1 in hereditary head and neck paraganglioma families from the Netherlands.
American journal of human genetics - 1 Aug 1998
van Schothorst E M, Jansen J C, Grooters E, Prins D E, Wiersinga J J, van der Mey A G, van Ommen G J, Devilee P, Cornelisse C J
Abstract excerpt
PGL1, a gene responsible for hereditary paragangliomas of the head and neck, recently was mapped to a 2-cM interval on chromosome 11q22-q23, by linkage and haplotype-sharing analysis of a large multibranch Dutch family. We determined the disease-linked haplotype, as defined by 13 markers encompas...
Topics
- Chromosome Mapping
- Chromosomes, Human, Pair 11
- DNA
- Family
- Female
- Genetic Markers
- Genotype
- Head and Neck Neoplasms
- Humans
- Lymphocytes
- Male
- Netherlands
- Nuclear Family
- Paraganglioma
- Pedigree
- Polymerase Chain Reaction