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Article

Founder effect at PGL1 in hereditary head and neck paraganglioma families from the Netherlands.

American journal of human genetics - 1 Aug 1998

van Schothorst E M, Jansen J C, Grooters E, Prins D E, Wiersinga J J, van der Mey A G, van Ommen G J, Devilee P, Cornelisse C J

Abstract excerpt

PGL1, a gene responsible for hereditary paragangliomas of the head and neck, recently was mapped to a 2-cM interval on chromosome 11q22-q23, by linkage and haplotype-sharing analysis of a large multibranch Dutch family. We determined the disease-linked haplotype, as defined by 13 markers encompassing a large interval on 11q21-q23, in 10 additional families ascertained from the same geographical locale. Alleles...

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Identifiers

PMID: 9683583
DOI: 10.1086/301951
PMCID: PMC1377293

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