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Article

Structure of the human APO‐1 gene

1 Dec 1994

Abstract excerpt

APO-1/Fas (CD95) is a type 1 transmembrane protein that belongs to the tumor necrosis factor/nerve growth factor receptor family characterized by cysteine-rich extracellular domains. Cross-linking of APO-1 mediates apoptosis in a variety of cells. In the present study we report the isolation and characterization of the human APO-1 gene spanning approximately 25 kb of human chromosome 10. The gene consists of nine...

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PMID: 7528667
DOI: 10.1002/eji.1830241221

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