Article
Long-term treatment of canine cyclic hematopoiesis with recombinant canine stem cell factor.
Blood - 1 Jan 1995
Dale D C, Rodger E, Cebon J, Ramesh N, Hammond W P, Zsebo K M
Abstract excerpt
Grey collie dogs have cyclic fluctuations in their blood cell counts caused by a regulatory defect of hematopoietic stem cells. To examine the role of stem cell factor (SCF) or its receptor in this disorder, we investigated the stimulatory effects of recombinant canine SCF (rc-SCF) on in vitro ma...
Topics
- Animals
- Base Sequence
- Bone Marrow
- Cells, Cultured
- Colony-Forming Units Assay
- Dog Diseases
- Dogs
- Drug Synergism
- Drug Therapy, Combination
- Female
- Granulocyte Colony-Stimulating Factor
- Granulocytes
- Hematologic Diseases
- Hematopoiesis
- Hematopoietic Cell Growth Factors
- Macrophages
- Male
- Molecular Sequence Data
