Article
Diverse Lyme disease spirochetes bind integrin alpha IIb beta 3 on human platelets.
Infection and immunity - 1 Dec 1994
Coburn J, Barthold S W, Leong J M
Abstract excerpt
Lyme disease is a chronic, multisystemic infection caused by Borrelia burgdorferi sensu lato. An infectious strain of B. burgdorferi was previously shown to bind to human platelets via the integrin alpha IIb beta 3. In this study, a diverse group of Lyme disease spirochetes was tested for platelet- and alpha IIb beta 3-binding activity. This collection included representatives of each of the three species that...
Topics
- Antigens, Bacterial
- Antigens, Surface
- Bacterial Adhesion
- Bacterial Outer Membrane Proteins
- Bacterial Vaccines
- Blood Platelets
- Borrelia burgdorferi Group
- Gene Expression
- Integrins
- Lipoproteins
- Phenotype