Article
Platelet activation by a relapsing fever spirochaete results in enhanced bacterium-platelet interaction via integrin alphaIIbbeta3 activation.
Molecular microbiology - 1 Jan 2001
Alugupalli K R, Michelson A D, Barnard M R, Robbins D, Coburn J, Baker E K, Ginsberg M H, Schwan T G, Leong J M
Abstract excerpt
Borrelia hermsii, a spirochaete responsible for relapsing fever in humans, grows to high density in the bloodstream and causes thrombocytopenia. We show here that B. hermsii binds to human platelets. Extended culture in bacteriological medium resulted in both diminished infectivity in vivo and diminished platelet binding in vitro. Platelet binding was promoted by the platelet integrin alphaIIbbeta3: the bacterium...
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