Article
Solution structure of FK506 bound to the R42K, H87V double mutant of FKBP-12.
Biochemistry - 22 Nov 1994
Lepre C A, Pearlman D A, Cheng J W, DeCenzo M T, Livingston D J, Moore J M
Abstract excerpt
The binding of the FK506/FKBP-12 complex to calcineurin (CN), its putative target for immunosuppression, involves recognition of solvent-exposed regions of the ligand as well as FKBP-12 residues near the active site. The R42K, H87V double mutation of FKBP-12 decreases the CN affinity of the complex by 550-fold [Aldape, R. A., Futer, O., DeCenzo, M. T., Jarrett, B. P., Murcko, M. A., & Livingston, D. J. (1992) J....
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