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Article

Solution structure of the Legionella pneumophila Mip-rapamycin complex

17 Mar 2008

Abstract excerpt

BACKGROUND: Legionella pneumphila is the causative agent of Legionnaires' disease. A major virulence factor of the pathogen is the homodimeric surface protein Mip. It shows peptidyl-prolyl cis/trans isomerase activty and is a receptor of FK506 and rapamycin, which both inhibit its enzymatic function. Insight into the binding process may be used for the design of novel Mip inhibitors as potential drugs against...

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PMID: 18366641
DOI: 10.1186/1472-6807-8-17

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