[Detection of amino acids on the agretopes of pigeon cytochrome c derived peptide p43-58 specifically bound to mouse MHC class II allelic products].

Abstract excerpt

In our previous study it has been demonstrated that residues 46 and 54 on a pigeon cytochrome c derived peptide, 50V (AEGFSYTVANKNKGIT), work as agretopes (sites contact with MHC molecule) and residues 50 and 52 function as dominant epitopes (sites contact with TCR), when tri-molecular complexes are formed among 50V, I-Ab molecule and TCR. 50V was substituted from aspartic acid to valine at position 50 of p43-58...

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