Article
[Detection of amino acids on the agretopes of pigeon cytochrome c derived peptide p43-58 specifically bound to mouse MHC class II allelic products].
[Hokkaido igaku zasshi] The Hokkaido journal of medical science - 1 May 1994
Itoh Y
Abstract excerpt
In our previous study it has been demonstrated that residues 46 and 54 on a pigeon cytochrome c derived peptide, 50V (AEGFSYTVANKNKGIT), work as agretopes (sites contact with MHC molecule) and residues 50 and 52 function as dominant epitopes (sites contact with TCR), when tri-molecular complexes are formed among 50V, I-Ab molecule and TCR. 50V was substituted from aspartic acid to valine at position 50 of p43-58...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Columbidae
- Cytochrome c Group
- Epitopes
- Genes, MHC Class II
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- Peptides