Influence of donor age on vinblastine-induced chromosome malsegregation in cultured peripheral lymphocytes.

doi:10.1093/mutage/17.1.83

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Article

Influence of donor age on vinblastine-induced chromosome malsegregation in cultured peripheral lymphocytes.

Mutagenesis - 1 Jan 2002

Leopardi Paola, Marcon Francesca, Dobrowolny Gabriella, Zijno Andrea, Crebelli Riccardo

Abstract excerpt

The incidence of spontaneous aneuploidy in human somatic and germ cells is known to be positively associated with aging. However, the influence of age on the individual susceptibility to chemically induced chromosome malsegregation has not been elucidated. In this study the spindle poison vinblastine (VBL) was used as a model compound to assess the influence of donor age on chemically induced chromosome...

Topics

Adult
Aging
Aneuploidy
Cells, Cultured
Chromosome Segregation
Chromosomes, Human
Chromosomes, Human, Pair 8
Cytochalasin B
Drug Resistance
Female
Genetic Variation
Humans
In Situ Hybridization, Fluorescence
Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 11752239
DOI: 10.1093/mutage/17.1.83

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Male

Micronucleus Tests

Middle Aged

Nondisjunction, Genetic