Article
Induction of chromosome aberrations by styrene and vinylacetate in cultured human lymphocytes: dependence on erythrocytes.
Mutation research - 1 Jan 2000
Jantunen K, Mäki-Paakkanen J, Norppa H
Abstract excerpt
Two vinyl monomers, styrene and vinylacetate, were tested for their ability to induce chromosome aberrations in cultured human lymphocytes. The effects of a 24-h treatment (48 h after culture initiation) were studied both in whole-blood cultures (with 2 X 10(8) erythrocytes/ml) and in isolated lymphocytes (with 4000 erythrocytes/ml). Styrene produced a clear dose-dependent increase in chromatid-type aberrations...
Topics
- Biotransformation
- Cells, Cultured
- Chromatids
- Chromosome Aberrations
- Dose-Response Relationship, Drug
- Erythrocytes
- Humans
- Lymphocytes
- Mitosis
- Mutation
- Styrene