Article
Gene structure, polymorphism and mapping of the human endothelial nitric oxide synthase gene.
Biochemical and biophysical research communications - 15 Feb 1994
Nadaud S, Bonnardeaux A, Lathrop M, Soubrier F
Abstract excerpt
Endothelium-derived relaxing factor (EDRF)/nitric oxide (NO) is synthesized from L-Arginine by the endothelial, constitutive, NO synthase. No facilitate genetic studies, we have cloned the human endothelial NO synthase gene and determined its structure. The gene is composed of 26 exons, ranging f...
Topics
- Alleles
- Amino Acid Oxidoreductases
- Base Sequence
- Chromosome Mapping
- Chromosomes, Human, Pair 7
- Cloning, Molecular
- Cosmids
- DNA Primers
- DNA, Satellite
- Endothelium
- Exons
- Female
- Genomic Library
- Humans
- Introns
- Lung
- Molecular Sequence Data
- Nitric Oxide Synthase