Article
Reversion of a polymerase-defective integrated HIV-1 genome.
AIDS research and human retroviruses - 1 Oct 1993
Quillent C, Dumey N, Dauguet C, Clavel F
Abstract excerpt
The 8E5 clonal cell line, derived from HIV-1-infected CEM cells, carries a single, reverse transcriptase (RT)-defective copy of an integrated HIV genome. The absence of RT production is a consequence of a frame shift in the pol gene, due to the addition of a single base at position 3241. We repor...
Topics
- Base Sequence
- Cell Line
- Defective Viruses
- Genome, Viral
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- RNA-Directed DNA Polymerase
- Sequence Analysis, DNA