Article
Autoantigen inhibits apoptosis of a human B cell leukemia that produces pathogenic rheumatoid factor.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1993
Kobayashi R, Rassenti L Z, Meisenholder G, Carson D A, Kipps T J
Abstract excerpt
We studied a variant CD5- B cell chronic lymphocytic leukemia (CLL) cell population that produces pathologic IgM kappa rheumatoid factor autoantibodies. In contrast to common CD5+ B cell CLL, this variant leukemia cell population displays intraclonal diversity in its expressed Ig V genes, similar...
Topics
- Antigens, CD
- Apoptosis
- Autoantigens
- Base Sequence
- CD5 Antigens
- Cytokines
- DNA, Neoplasm
- Gene Rearrangement, B-Lymphocyte
- Genetic Variation
- Humans
- Immunoglobulin G
- In Vitro Techniques
- Leukemia, B-Cell
- Molecular Sequence Data
- Phenotype
- Repetitive Sequences, Nucleic Acid
- Rheumatoid Factor