Article
Variation in N-linked carbohydrate chains in different batches of two chimeric monoclonal IgG1 antibodies produced by different murine SP2/0 transfectoma cell subclones.
Glycoconjugate journal - 1 Jun 1995
Bergwerff A A, Stroop C J, Murray B, Holtorf A P, Pluschke G, Van Oostrum J, Kamerling J P, Vliegenthart J F
Abstract excerpt
Two chimeric human/murine monoclonal antibodies were constructed by substitution of the murine constant regions with human gamma 1 and kappa constant regions for heavy and light chains, respectively. The chimeric human/murine molecules are anti-idiotypic antibodies, meaning that they were directe...
Topics
- Animals
- Antibodies, Monoclonal
- Carbohydrate Conformation
- Carbohydrate Sequence
- Genetic Variation
- Humans
- Immunoglobulin G
- Mice
- Molecular Sequence Data
- Multiple Myeloma
- Recombinant Fusion Proteins
- Transfection
- Tumor Cells, Cultured